2BCV

DNA polymerase lambda in complex with Dttp and a DNA duplex containing an unpaired Dtmp

Summary for 2BCV

• Entry DOI: 10.2210/pdb2bcv/pdb
• Related: 2BCQ 2BCR 2BCS 2BCU
• Descriptor: 5'-D(P*GP*CP*CP*G)-3', 5'-D(*CP*AP*GP*TP*AP*(O2C))-3', 5'-D(*CP*GP*GP*CP*AP*GP*TP*TP*AP*CP*TP*G)-3', ... (8 entities in total)
• Functional Keywords: misalignment, extrahelical, mutagenesis, mutation, deletion, streisinger, slippage, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9UGP5
• Total number of polymer chains: 4
• Total formula weight: 44718.63

Authors

Garcia-Diaz, M.,Bebenek, K.,Krahn, J.M.,Pedersen, L.C.,Kunkel, T.A. (deposition date: 2005-10-19, release date: 2006-03-07, Last modification date: 2023-08-23)

• Primary citation: Garcia-Diaz, M.,Bebenek, K.,Krahn, J.M.,Pedersen, L.C.,Kunkel, T.A.; Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase; Cell(Cambridge,Mass.), 124:331-342, 2006; PubMed: 16439207; DOI: 10.1016/j.cell.2005.10.039

Experimental method

X-RAY DIFFRACTION (2 Å)