2B52
Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562
Summary for 2B52
Entry DOI | 10.2210/pdb2b52/pdb |
Related | 2B53 2B54 2B55 |
Descriptor | Cell division protein kinase 2, 1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA (3 entities in total) |
Functional Keywords | protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34414.01 |
Authors | Muckelbauer, J. (deposition date: 2005-09-27, release date: 2005-10-11, Last modification date: 2024-02-14) |
Primary citation | Yue, E.W.,Dimeo, S.V.,Higley, C.A.,Markwalder, J.A.,Burton, C.R.,Benfield, P.A.,Grafstrom, R.H.,Cox, S.,Muckelbauer, J.K.,Smallwood, A.,Chen, H.,Chang, C.-H.,Trainor, G.L.,Seitz, S.P. Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. Part 4: Heterocycles at C3 Bioorg.Med.Chem.Lett., 14:343-346, 2004 Cited by PubMed: 14698155DOI: 10.1016/j.bmcl.2003.11.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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