2AZX

Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase

Summary for 2AZX

Entry DOI	10.2210/pdb2azx/pdb
Related	1R6T 1R6U
Descriptor	72-MER, Tryptophanyl-tRNA synthetase, SULFATE ION, ... (7 entities in total)
Functional Keywords	two synthetase-trna complex with distinct conformations, association complex and dissociation complex, ligase-rna complex, ligase/rna
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P23381
Total number of polymer chains	4
Total formula weight	159325.77
Authors	Yang, X.L.,Otero, F.J.,Ewalt, K.L.,Liu, J.,Swairjo, M.A.,Kohrer, C.,RajBhandary, U.L.,Skene, R.J.,McRee, D.E.,Schimmel, P. (deposition date: 2005-09-12, release date: 2006-08-01, Last modification date: 2011-07-13)
Primary citation	Yang, X.L.,Otero, F.J.,Ewalt, K.L.,Liu, J.,Swairjo, M.A.,Kohrer, C.,RajBhandary, U.L.,Skene, R.J.,McRee, D.E.,Schimmel, P. Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis. Embo J., 25:2919-2929, 2006 Cited by PubMed: 16724112 DOI: 10.1038/sj.emboj.7601154 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation