2AZX

Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, D)	72-MER	polymer	75	24180.4	2
2	C, D (A, B)	Tryptophanyl-tRNA synthetase	polymer	477	54591.6	2	UniProt (P23381) Pfam (PF00458) Pfam (PF00579)	Homo sapiens (human)	Tryptophan--tRNA ligase, TrpRS, IFP53, hWRS
3	E, F, G, H, K... (A, B)	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
4	I, J, R (A, B)	TRYPTOPHAN	non-polymer		204.2	3	Chemie (TRP)
5	Q (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	S, T (B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
7	U, V, W, X (C, D, A, B)	water	water		18.0	22	Chemie (HOH)

Sequence modifications

A, B: 1 - 471 (UniProt: P23381)

PDB	External Database	Details
Mse 1	Met 1	modified residue
Mse 42	Met 42	modified residue
Mse 48	Met 48	modified residue
Mse 143	Met 143	modified residue
Mse 169	Met 169	modified residue
Mse 195	Met 195	modified residue
Gly 213	Ser 213	variant
Asp 214	Tyr 214	variant
Mse 241	Met 241	modified residue
Mse 243	Met 243	modified residue
Mse 319	Met 319	modified residue
Mse 350	Met 350	modified residue
Mse 401	Met 401	modified residue
Mse 425	Met 425	modified residue
Mse 461	Met 461	modified residue
His 472	-	expression tag
His 473	-	expression tag
His 474	-	expression tag
His 475	-	expression tag
His 476	-	expression tag
His 477	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	157544.0
Non-Polymers*	Number of molecules	16
	Total formula weight	1781.8
All*	Total formula weight	159325.8

*Water molecules are not included.