2AZX
Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001525 | biological_process | angiogenesis |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045765 | biological_process | regulation of angiogenesis |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001525 | biological_process | angiogenesis |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0016874 | molecular_function | ligase activity |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0019904 | molecular_function | protein domain specific binding |
| B | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0045765 | biological_process | regulation of angiogenesis |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 701 |
| Chain | Residue |
| B | HIS170 |
| B | HIS173 |
| B | SER351 |
| B | ALA352 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 702 |
| Chain | Residue |
| A | ALA352 |
| A | SER353 |
| A | HIS170 |
| A | HIS173 |
| A | LYS349 |
| A | MSE350 |
| A | SER351 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 703 |
| Chain | Residue |
| B | ASP142 |
| B | MSE143 |
| B | ASN144 |
| B | GLN145 |
| B | HOH1009 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 704 |
| Chain | Residue |
| A | HIS140 |
| A | ASP142 |
| A | ASN144 |
| A | GLN145 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 705 |
| Chain | Residue |
| B | ALA352 |
| B | PRO355 |
| B | ASN356 |
| B | PHE360 |
| B | MG901 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 706 |
| Chain | Residue |
| B | ARG141 |
| B | ARG321 |
| B | LYS331 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 707 |
| Chain | Residue |
| A | ASP354 |
| A | PRO355 |
| A | ASN356 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 708 |
| Chain | Residue |
| A | THR207 |
| A | LEU208 |
| A | ASP209 |
| A | LYS253 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 709 |
| Chain | Residue |
| B | THR364 |
| B | ALA365 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 710 |
| Chain | Residue |
| B | THR453 |
| B | ASP454 |
| B | GLU455 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 901 |
| Chain | Residue |
| B | SER351 |
| B | ASP354 |
| B | SER357 |
| B | SER358 |
| B | SO4705 |
| site_id | BC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TRP A 601 |
| Chain | Residue |
| A | TYR159 |
| A | THR160 |
| A | GLY161 |
| A | ARG162 |
| A | GLY163 |
| A | GLN194 |
| A | THR196 |
| A | GLU199 |
| A | GLN284 |
| A | CYS309 |
| A | GLN313 |
| A | PHE317 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TRP A 602 |
| Chain | Residue |
| A | LEU174 |
| A | ILE178 |
| A | PHE406 |
| A | GLU408 |
| A | LEU441 |
| A | ARG448 |
| site_id | BC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TRP B 603 |
| Chain | Residue |
| B | TYR159 |
| B | THR160 |
| B | GLY161 |
| B | ARG162 |
| B | GLY163 |
| B | GLN194 |
| B | THR196 |
| B | GLU199 |
| B | GLN284 |
| B | CYS309 |
| B | GLN313 |
| B | PHE317 |
| B | HOH1005 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 801 |
| Chain | Residue |
| B | THR207 |
| B | LEU208 |
| B | ASP209 |
| B | LYS253 |
| B | HOH1021 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P32921","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| A | ALA352 | |
| A | LYS349 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| B | ALA352 | |
| B | LYS349 |
