2AZX

Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase

2AZX の概要

• エントリーDOI: 10.2210/pdb2azx/pdb
• 関連するPDBエントリー: 1R6T 1R6U
• 分子名称: 72-MER, Tryptophanyl-tRNA synthetase, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: two synthetase-trna complex with distinct conformations, association complex and dissociation complex, ligase-rna complex, ligase/rna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P23381
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 159325.77

構造登録者

Yang, X.L.,Otero, F.J.,Ewalt, K.L.,Liu, J.,Swairjo, M.A.,Kohrer, C.,RajBhandary, U.L.,Skene, R.J.,McRee, D.E.,Schimmel, P. (登録日: 2005-09-12, 公開日: 2006-08-01, 最終更新日: 2011-07-13)

• 主引用文献: Yang, X.L.,Otero, F.J.,Ewalt, K.L.,Liu, J.,Swairjo, M.A.,Kohrer, C.,RajBhandary, U.L.,Skene, R.J.,McRee, D.E.,Schimmel, P.; Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.; Embo J., 25:2919-2929, 2006; PubMed: 16724112; DOI: 10.1038/sj.emboj.7601154

実験手法

X-RAY DIFFRACTION (2.8 Å)