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2ATI

Glycogen Phosphorylase Inhibitors

Summary for 2ATI
Entry DOI10.2210/pdb2ati/pdb
Related1WUT 1WUY 1WV0 1WV1
DescriptorGlycogen phosphorylase, liver form, alpha-D-glucopyranose, N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA, ... (5 entities in total)
Functional Keywordsglycogen phosphorylase, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight195822.56
Authors
Primary citationKlabunde, T.,Wendt, K.U.,Kadereit, D.,Brachvogel, V.,Burger, H.J.,Herling, A.W.,Oikonomakos, N.G.,Kosmopoulou, M.N.,Schmoll, D.,Sarubbi, E.,von Roedern, E.,Defossa, E.
Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
J.Med.Chem., 48:6178-6193, 2005
Cited by
PubMed: 16190745
DOI: 10.1021/jm049034y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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