2AOU

Histamine Methyltransferase Complexed with the Antimalarial Drug Amodiaquine

Summary for 2AOU

• Entry DOI: 10.2210/pdb2aou/pdb
• Related: 1JQD 1JQE 2AOT 2AOV 2AOW 2AOX
• Descriptor: Histamine N-methyltransferase, 4-[(7-CHLOROQUINOLIN-4-YL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL, ... (4 entities in total)
• Functional Keywords: classic methyltransferase fold, protein-drug complex, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P50135 P50135
• Total number of polymer chains: 2
• Total formula weight: 68121.48

Authors

Horton, J.R.,Sawada, K.,Nishibori, M.,Cheng, X. (deposition date: 2005-08-14, release date: 2005-09-13, Last modification date: 2023-11-15)

• Primary citation: Horton, J.R.,Sawada, K.,Nishibori, M.,Cheng, X.; Structural basis for inhibition of histamine N-methyltransferase by diverse drugs; J.Mol.Biol., 353:334-344, 2005; PubMed: 16168438; DOI: 10.1016/j.jmb.2005.08.040

Experimental method

X-RAY DIFFRACTION (2.3 Å)