2AOU
Histamine Methyltransferase Complexed with the Antimalarial Drug Amodiaquine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histamine N-methyltransferase | polymer | 292 | 33349.0 | 1 | UniProt (P50135) Pfam (PF13489) | Homo sapiens (human) | HMT |
| 2 | B (B) | Histamine N-methyltransferase | polymer | 292 | 33349.0 | 1 | UniProt (P50135) Pfam (PF13489) | Homo sapiens (human) | |
| 3 | C, D, E, F (A, B) | 4-[(7-CHLOROQUINOLIN-4-YL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL | non-polymer | 355.9 | 4 | Chemie (CQA) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A: 1 - 292 (UniProt: P50135)
B: 1 - 292 (UniProt: P50135)
| PDB | External Database | Details |
|---|---|---|
| Cys 82 | Cys 82 | modified residue |
| Cso 217 | Cys 217 | modified residue |
| Dcy 248 | Cys 248 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Cso 82 | Cys 82 | modified residue |
| Cys 217 | Cys 217 | modified residue |
| Cys 248 | Cys 248 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66698.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1423.4 | |
| All* | Total formula weight | 68121.5 |
