2AOU
Histamine Methyltransferase Complexed with the Antimalarial Drug Amodiaquine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001692 | biological_process | histamine metabolic process |
| A | 0001695 | biological_process | histamine catabolic process |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006548 | biological_process | L-histidine catabolic process |
| A | 0007585 | biological_process | respiratory gaseous exchange by respiratory system |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008170 | molecular_function | N-methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0046539 | molecular_function | histamine N-methyltransferase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0001692 | biological_process | histamine metabolic process |
| B | 0001695 | biological_process | histamine catabolic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006548 | biological_process | L-histidine catabolic process |
| B | 0007585 | biological_process | respiratory gaseous exchange by respiratory system |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008170 | molecular_function | N-methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0046539 | molecular_function | histamine N-methyltransferase activity |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CQA B 400 |
| Chain | Residue |
| B | TYR15 |
| B | TRP179 |
| B | TRP183 |
| B | CYS196 |
| B | PHE243 |
| B | GLU246 |
| B | HOH535 |
| B | PHE19 |
| B | GLU28 |
| B | SER91 |
| B | GLN94 |
| B | GLN143 |
| B | TYR146 |
| B | TYR147 |
| B | VAL173 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CQA A 402 |
| Chain | Residue |
| A | TYR15 |
| A | PHE19 |
| A | GLU28 |
| A | GLN94 |
| A | GLN143 |
| A | TYR146 |
| A | TYR147 |
| A | VAL173 |
| A | TRP179 |
| A | TRP183 |
| A | CYS196 |
| A | PHE243 |
| A | GLU246 |
| A | HOH520 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CQA B 401 |
| Chain | Residue |
| B | ARG6 |
| B | SER7 |
| B | TRP183 |
| B | GLY187 |
| B | PHE190 |
| B | PRO191 |
| B | ASP193 |
| B | TYR198 |
| B | THR245 |
| B | THR247 |
| B | HOH483 |
| B | HOH499 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CQA A 403 |
| Chain | Residue |
| A | ASP180 |
| A | TRP183 |
| A | LYS184 |
| A | GLY187 |
| A | PHE190 |
| A | PRO191 |
| A | TYR198 |
| A | THR245 |
| A | GLU246 |
| A | THR247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {} |
| Chain | Residue | Details |
