2AOE
crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog CA-P2
Summary for 2AOE
Entry DOI | 10.2210/pdb2aoe/pdb |
Related | 1A8K 1A94 2AOC 2AOD 2AOF 2AOG 2AOH 2AOI 2AOJ |
Related PRD ID | PRD_000349 |
Descriptor | POL POLYPROTEIN, SODIUM ION, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | hiv-1 protease, substrate analog, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (BH5 ISOLATE) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04587 |
Total number of polymer chains | 2 |
Total formula weight | 22802.12 |
Authors | Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Liu, F.,Chen, X.,Tozser, J.,Harrison, R.W.,Weber, I.T. (deposition date: 2005-08-12, release date: 2006-01-17, Last modification date: 2023-08-23) |
Primary citation | Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Liu, F.,Chen, X.,Tozser, J.,Harrison, R.W.,Weber, I.T. Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. Febs J., 272:5265-5277, 2005 Cited by PubMed: 16218957DOI: 10.1111/j.1742-4658.2005.04923.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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