2AM9

Crystal structure of human androgen receptor ligand binding domain in complex with testosterone

Summary for 2AM9

Related2AMA 2AMB
DescriptorAndrogen receptor, SULFATE ION, TESTOSTERONE, ... (6 entities in total)
Functional Keywordsnuclear receptor, androgen receptor, ligand binding domain, testosterone, agonist, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological sourceHomo sapiens (human)
Cellular locationNucleus P10275
Total number of polymer chains1
Total molecular weight31627.02
Authors
Pereira de Jesus-Tran, K.,Cote, P.-L.,Cantin, L.,Blanchet, J.,Labrie, F.,Breton, R. (deposition date: 2005-08-09, release date: 2006-05-16, Last modification date: 2011-07-13)
Primary citation
Pereira de Jesus-Tran, K.,Cote, P.-L.,Cantin, L.,Blanchet, J.,Labrie, F.,Breton, R.
Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15:987-999, 2006
PubMed: 16641486 (PDB entries with the same primary citation)
DOI: 10.1110/ps.051905906
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.64 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.251801.3%5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2am9
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Molmil generated image of 2am9
rotated about x axis by 90°
Molmil generated image of 2am9
rotated about y axis by 90°