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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2AM9

Crystal structure of human androgen receptor ligand binding domain in complex with testosterone

Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 1001
ChainResidue
AHOH43
AHOH215
ASER696
APHE697
ALYS777
AARG779
ASER853
site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE TES A 1000
ChainResidue
AGLN711
AMET745
AMET749
AARG752
APHE764
AMET780
ATHR877
AMET895
ALEU704
AASN705
site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE DTT A 1003
ChainResidue
AHOH84
AHOH107
AHOH143
ACYS686
APRO766
AGLN798
AILE799
ATHR800
site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 1002
ChainResidue
AHIS789
ATRP796
ALEU821
ALYS822
AASN823
AGLN824
ALYS825
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15563469","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16641486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17591767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25091737","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AMA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PKL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PNU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q7I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q7J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YHD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YLO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L3Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OEA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OFR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JJM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15563469","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16641486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17591767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25091737","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AM9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AMA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PKL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q7I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q7J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YHD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YLO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L3Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OEA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OFR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JJM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsSite: {"description":"Interaction with coactivator LXXL and FXXFY motifs","evidences":[{"source":"PubMed","id":"25091737","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsSite: {"description":"Interaction with coactivator FXXLF and FXXFY motifs","evidences":[{"source":"PubMed","id":"25091737","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by CSK","evidences":[{"source":"PubMed","id":"17045208","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19345326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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