2AL4
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614.
Summary for 2AL4
Entry DOI | 10.2210/pdb2al4/pdb |
Related | 1LBC 1MM6 1MM7 2AL5 |
Descriptor | Glutamate receptor 2, ZINC ION, (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, ... (5 entities in total) |
Functional Keywords | ionotropic glutamate receptor, glur2, ligand binding core, s1s2, quisqualate, cx614, modulator, membrane protein |
Biological source | Rattus norvegicus (Norway rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 6 |
Total formula weight | 177860.68 |
Authors | Jin, R.,Clark, S.,Weeks, A.M.,Dudman, J.T.,Gouaux, E.,Partin, K.M. (deposition date: 2005-08-04, release date: 2005-10-25, Last modification date: 2023-08-23) |
Primary citation | Jin, R.,Clark, S.,Weeks, A.M.,Dudman, J.T.,Gouaux, E.,Partin, K.M. Mechanism of positive allosteric modulators acting on AMPA receptors. J.Neurosci., 25:9027-9036, 2005 Cited by PubMed: 16192394DOI: 10.1523/JNEUROSCI.2567-05.2005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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