2ACL

Liver X-Receptor alpha Ligand Binding Domain with SB313987

Summary for 2ACL

• Entry DOI: 10.2210/pdb2acl/pdb
• Descriptor: Retinoic acid receptor RXR-alpha, Oxysterols receptor LXR-alpha, RETINOIC ACID, ... (5 entities in total)
• Functional Keywords: nuclear hormone receptor ligand binding domain transcription factor three layered a-helix fold, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P19793 Q9Z0Y9
• Total number of polymer chains: 8
• Total formula weight: 222167.87

Authors

Jaye, M.C.,Krawiec, J.A.,Campobasso, N.,Smallwood, A.,Qiu, C.,Lu, Q.,Kerrigan, J.J. (deposition date: 2005-07-19, release date: 2005-09-20, Last modification date: 2024-02-14)

Primary citation

Jaye, M.C.,Krawiec, J.A.,Campobasso, N.,Smallwood, A.,Qiu, C.,Lu, Q.,Kerrigan, J.J.,De Los Frailes Alvaro, M.,Laffitte, B.,Liu, W.S.,Marino, J.P.,Meyer, C.R.,Nichols, J.A.,Parks, D.J.,Perez, P.,Sarov-Blat, L.,Seepersaud, S.D.,Steplewski, K.M.,Thompson, S.K.,Wang, P.,Watson, M.A.,Webb, C.L.,Haigh, D.,Caravella, J.A.,Macphee, C.H.,Willson, T.M.,Collins, J.L.
Discovery of substituted maleimides as liver x receptor agonists and determination of a ligand-bound crystal structure.
J.Med.Chem., 48:5419-5422, 2005

PubMed Abstract: Substituted 3-(phenylamino)-1H-pyrrole-2,5-diones were identified from a high throughput screen as inducers of human ATP binding cassette transporter A1 expression. Mechanism of action studies led to the identification of GSK3987 as an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC(50)s of 40 nM, profiles as an LXR agonist in functional assays, and activates LXR though a mechanism that is similar to first generation LXR agonists.

PubMed: 16107141
DOI: 10.1021/jm050532w

Experimental method

X-RAY DIFFRACTION (2.8 Å)