2ACL

Liver X-Receptor alpha Ligand Binding Domain with SB313987

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003707	molecular_function	nuclear steroid receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
B	0003677	molecular_function	DNA binding
B	0004879	molecular_function	nuclear receptor activity
B	0006629	biological_process	lipid metabolic process
C	0003677	molecular_function	DNA binding
C	0003707	molecular_function	nuclear steroid receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008270	molecular_function	zinc ion binding
D	0003677	molecular_function	DNA binding
D	0004879	molecular_function	nuclear receptor activity
D	0006629	biological_process	lipid metabolic process
E	0003677	molecular_function	DNA binding
E	0003707	molecular_function	nuclear steroid receptor activity
E	0005634	cellular_component	nucleus
E	0006355	biological_process	regulation of DNA-templated transcription
E	0008270	molecular_function	zinc ion binding
F	0003677	molecular_function	DNA binding
F	0004879	molecular_function	nuclear receptor activity
F	0006629	biological_process	lipid metabolic process
G	0003677	molecular_function	DNA binding
G	0003707	molecular_function	nuclear steroid receptor activity
G	0005634	cellular_component	nucleus
G	0006355	biological_process	regulation of DNA-templated transcription
G	0008270	molecular_function	zinc ion binding
H	0003677	molecular_function	DNA binding
H	0004879	molecular_function	nuclear receptor activity
H	0006629	biological_process	lipid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE L05 B 101

Chain	Residue
B	PHE252
B	PHE255
B	THR256
B	ALA259
B	SER262
B	PHE313
B	GLY328
B	LEU329
B	HIS419

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE L05 D 102

Chain	Residue
D	PHE255
D	THR256
D	ALA259
D	SER262
D	ILE293
D	MET296
D	THR300
D	PHE313
D	ALA327
D	GLY328
D	LEU329
D	HIS419
D	GLN422
D	LEU426

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE L05 F 103

Chain	Residue
F	PHE252
F	PHE255
F	THR256
F	ALA259
F	ILE293
F	MET296
F	PHE313
F	ALA327
F	GLY328
F	LEU329
F	HIS419
F	LEU426
F	TRP441

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE L05 H 104

Chain	Residue
H	PHE252
H	PHE255
H	THR256
H	ALA259
H	PHE313
H	GLY328
H	LEU329
H	HIS419
H	GLN422
H	TRP441

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE REA G 501

Chain	Residue
G	ALA271
G	ALA272
G	GLN275
G	ASN306
G	PHE313
G	ARG316
G	LEU326
G	ALA327
G	CYS432

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE REA A 502

Chain	Residue
A	ALA271
A	ALA272
A	GLN275
A	PHE313
A	ARG316
A	LEU326
A	ALA327
A	CYS432

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE REA C 503

Chain	Residue
C	ALA271
C	ALA272
C	PHE313
C	ARG316
C	LEU326
C	ALA327
C	ILE345
C	CYS432

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE REA E 504

Chain	Residue
E	ALA271
E	ALA272
E	GLN275
E	PHE313
E	ARG316
E	LEU326
E	ALA327

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6

Chain	Residue	Details
A	ARG316
A	ALA327
C	ARG316
C	ALA327
E	ARG316
E	ALA327
G	ARG316
G	ALA327

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER259
C	SER259
E	SER259
G	SER259

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700

Chain	Residue	Details
A	SER260
C	SER260
E	SER260
G	SER260

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