2ACL
Liver X-Receptor alpha Ligand Binding Domain with SB313987
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0006629 | biological_process | lipid metabolic process |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004879 | molecular_function | nuclear receptor activity |
| D | 0006629 | biological_process | lipid metabolic process |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003707 | molecular_function | nuclear steroid receptor activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0008270 | molecular_function | zinc ion binding |
| F | 0003677 | molecular_function | DNA binding |
| F | 0004879 | molecular_function | nuclear receptor activity |
| F | 0006629 | biological_process | lipid metabolic process |
| G | 0003677 | molecular_function | DNA binding |
| G | 0003707 | molecular_function | nuclear steroid receptor activity |
| G | 0005634 | cellular_component | nucleus |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0008270 | molecular_function | zinc ion binding |
| H | 0003677 | molecular_function | DNA binding |
| H | 0004879 | molecular_function | nuclear receptor activity |
| H | 0006629 | biological_process | lipid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE L05 B 101 |
| Chain | Residue |
| B | PHE252 |
| B | PHE255 |
| B | THR256 |
| B | ALA259 |
| B | SER262 |
| B | PHE313 |
| B | GLY328 |
| B | LEU329 |
| B | HIS419 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE L05 D 102 |
| Chain | Residue |
| D | PHE255 |
| D | THR256 |
| D | ALA259 |
| D | SER262 |
| D | ILE293 |
| D | MET296 |
| D | THR300 |
| D | PHE313 |
| D | ALA327 |
| D | GLY328 |
| D | LEU329 |
| D | HIS419 |
| D | GLN422 |
| D | LEU426 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE L05 F 103 |
| Chain | Residue |
| F | PHE252 |
| F | PHE255 |
| F | THR256 |
| F | ALA259 |
| F | ILE293 |
| F | MET296 |
| F | PHE313 |
| F | ALA327 |
| F | GLY328 |
| F | LEU329 |
| F | HIS419 |
| F | LEU426 |
| F | TRP441 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE L05 H 104 |
| Chain | Residue |
| H | PHE252 |
| H | PHE255 |
| H | THR256 |
| H | ALA259 |
| H | PHE313 |
| H | GLY328 |
| H | LEU329 |
| H | HIS419 |
| H | GLN422 |
| H | TRP441 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE REA G 501 |
| Chain | Residue |
| G | ALA271 |
| G | ALA272 |
| G | GLN275 |
| G | ASN306 |
| G | PHE313 |
| G | ARG316 |
| G | LEU326 |
| G | ALA327 |
| G | CYS432 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE REA A 502 |
| Chain | Residue |
| A | ALA271 |
| A | ALA272 |
| A | GLN275 |
| A | PHE313 |
| A | ARG316 |
| A | LEU326 |
| A | ALA327 |
| A | CYS432 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE REA C 503 |
| Chain | Residue |
| C | ALA271 |
| C | ALA272 |
| C | PHE313 |
| C | ARG316 |
| C | LEU326 |
| C | ALA327 |
| C | ILE345 |
| C | CYS432 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE REA E 504 |
| Chain | Residue |
| E | ALA271 |
| E | ALA272 |
| E | GLN275 |
| E | PHE313 |
| E | ARG316 |
| E | LEU326 |
| E | ALA327 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 238 |
| Details | Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 242 |
| Details | Region: {"description":"Transactivation AF-2; required for ligand-dependent transactivation function; mediates interaction with CCAR2","evidences":[{"source":"UniProtKB","id":"Q13133","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
