2A7Q

Crystal structure of human dCK complexed with clofarabine and ADP

Summary for 2A7Q

• Entry DOI: 10.2210/pdb2a7q/pdb
• Related: 1P5Z 1p60 1p61 1p62
• Descriptor: Deoxycytidine kinase, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: alpha/beta parallel beta-sheet of 5 strands, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P27707
• Total number of polymer chains: 1
• Total formula weight: 31589.96

Authors

Zhang, Y.,Secrist III, J.A.,Ealick, S.E. (deposition date: 2005-07-05, release date: 2006-01-24, Last modification date: 2023-08-23)

• Primary citation: Zhang, Y.,Secrist, J.A.,Ealick, S.E.; The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.; Acta Crystallogr.,Sect.D, 62:133-139, 2006; PubMed: 16421443; DOI: 10.1107/S0907444905034293

Experimental method

X-RAY DIFFRACTION (2.55 Å)