2A7Q
Crystal structure of human dCK complexed with clofarabine and ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Deoxycytidine kinase | polymer | 263 | 30834.8 | 1 | UniProt (P27707) Pfam (PF01712) | Homo sapiens (human) | dCK |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D (A) | 2-CHLORO-9-(2-DEOXY-2-FLUORO-B -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE | non-polymer | 303.7 | 1 | Chemie (CFB) | |||
| 5 | E (A) | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A: 1 - 260 (UniProt: P27707)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30834.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 755.2 | |
| All* | Total formula weight | 31590.0 |
