2A7Q
Crystal structure of human dCK complexed with clofarabine and ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Deoxycytidine kinase | polymer | 263 | 30834.8 | 1 | UniProt (P27707) Pfam (PF01712) | Homo sapiens (human) | dCK |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D (A) | 2-CHLORO-9-(2-DEOXY-2-FLUORO-B -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE | non-polymer | 303.7 | 1 | Chemie (CFB) PubChem (16760208) PubChem (23863210) PubChem (25886728) PubChem (25886729) PubChem (119182) PubChem (56973707) PubChem (354624) PubChem (60062256) PubChem (60148441) PubChem (466430) PubChem (57662100) PubChem (88941831) PubChem (87661437) PubChem (88936510) PubChem (89403438) PubChem (118117451) PubChem (118133660) PubChem (121225621) PubChem (121336841) PubChem (9882903) PubChem (9995171) PubChem (15719369) PubChem (126589832) PubChem (129030631) PubChem (142879040) PubChem (156573034) | |||
| 5 | E (A) | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A: 1 - 260 (UniProt: P27707)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30834.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 755.2 | |
| All* | Total formula weight | 31590.0 |
