2A6H

Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin

2A6H の概要

• エントリーDOI: 10.2210/pdb2a6h/pdb
• 関連するPDBエントリー: 1IW7 1SMY 2A68 2A69 2A6E
• 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (9 entities in total)
• 機能のキーワード: rna polymerase holoenzyme, streptolydigin, antibiotic, transcription regulation, riken structural genomics/proteomics initiative, rsgi, structural genomics, transferase
• 由来する生物種: Thermus thermophilus; 詳細
• 細胞内の位置: Cytoplasm : Q5SKW1
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 854782.62

構造登録者

Temiakov, D.,Zenkin, N.,Vassylyeva, M.N.,Perederina, A.,Tahirov, T.H.,Savkina, M.,Zorov, S.,Nikiforov, V.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Severinov, K.,Vassylyev, D.G.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2005-07-02, 公開日: 2005-09-20, 最終更新日: 2023-08-23)

• 主引用文献: Temiakov, D.,Zenkin, N.,Vassylyeva, M.N.,Perederina, A.,Tahirov, T.H.,Kashkina, E.,Savkina, M.,Zorov, S.,Nikiforov, V.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Severinov, K.,Vassylyev, D.G.; Structural basis of transcription inhibition by antibiotic streptolydigin.; Mol.Cell, 19:655-666, 2005; PubMed: 16167380; DOI: 10.1016/j.molcel.2005.07.020

実験手法

X-RAY DIFFRACTION (2.4 Å)