2A2X
Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12
Summary for 2A2X
Entry DOI | 10.2210/pdb2a2x/pdb |
Related | 2ANK |
Related PRD ID | PRD_000480 |
Descriptor | Thrombin light chain, Thrombin heavy chain, synthetic peptide, ... (5 entities in total) |
Functional Keywords | blood clotting, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 35589.62 |
Authors | Lange, U.E.W.,Baucke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. (deposition date: 2005-06-23, release date: 2006-11-14, Last modification date: 2023-08-23) |
Primary citation | Lange, U.E.W.,Baucke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety BIOORG.MED.CHEM.LETT., 16:2648-2653, 2006 Cited by PubMed: 16460939DOI: 10.1016/j.bmcl.2006.01.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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