2ANK
orally active thrombin inhibitors in complex with thrombin and an exosite decapeptide
Summary for 2ANK
Entry DOI | 10.2210/pdb2ank/pdb |
Related | 2A2X |
Related PRD ID | PRD_000480 |
Descriptor | Thrombin heavy chain, Thrombin light chain, synthetic peptide, ... (5 entities in total) |
Functional Keywords | blood clotting, hydrolase, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 35615.66 |
Authors | Lange, U.E.W.,Baucke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. (deposition date: 2005-08-11, release date: 2006-11-14, Last modification date: 2023-08-23) |
Primary citation | Lange, U.E.W.,Baucke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety BIOORG.MED.CHEM.LETT., 16:2648-2653, 2006 Cited by PubMed: 16460939DOI: 10.1016/j.bmcl.2006.01.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
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