2ZY0

Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide

Summary for 2ZY0

• Entry DOI: 10.2210/pdb2zy0/pdb
• Related: 1FBY 1MV9 1MVC 2ZXZ
• Descriptor: Retinoic acid receptor RXR-alpha, GRIP1 from Nuclear receptor coactivator 2, 4-[2-(1,1,3,3-tetramethyl-2,3-dihydro-1H-1,3-benzodisilol-5-yl)-1,3-dioxolan-2-yl]benzoic acid, ... (4 entities in total)
• Functional Keywords: transcription regulation, nuclear receptor, structural genomics, structural genomics consortium for research on gene expression, sgcges, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P19793 Q15596
• Total number of polymer chains: 4
• Total formula weight: 57669.01

Authors

Sato, Y.,Antony, P.,Rochel, N.,Moras, D.,Structural Genomics Consortium for Research on Gene Expression (SGCGES) (deposition date: 2009-01-09, release date: 2009-08-11, Last modification date: 2023-11-01)

• Primary citation: Lippert, W.P.,Burschka, C.,Gotz, K.,Kaupp, M.,Ivanova, D.,Gaudon, C.,Sato, Y.,Antony, P.,Rochel, N.,Moras, D.,Gronemeyer, H.,Tacke, R.; Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology; Chemmedchem, 4:1143-1152, 2009; PubMed: 19496083; DOI: 10.1002/cmdc.200900090

Experimental method

X-RAY DIFFRACTION (2.9 Å)