2Z3Q
Crystal structure of the IL-15/IL-15Ra complex
Summary for 2Z3Q
Entry DOI | 10.2210/pdb2z3q/pdb |
Related | 2Z3R |
Descriptor | Interleukin-15, Interleukin-15 receptor alpha chain (3 entities in total) |
Functional Keywords | protein-protein complex, cytokine-cytokine receptor complex, cytokine/cytokine receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform IL15-S48AA: Secreted. Isoform IL15-S21AA: Cytoplasm: P40933 Membrane; Single-pass type I membrane protein. Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space: Q13261 |
Total number of polymer chains | 4 |
Total formula weight | 49508.30 |
Authors | Chirifu, M.,Yamagata, Y.,Davis, S.J.,Ikemizu, S. (deposition date: 2007-06-05, release date: 2007-09-04, Last modification date: 2011-07-13) |
Primary citation | Chirifu, M.,Hayashi, C.,Nakamura, T.,Toma, S.,Shuto, T.,Kai, H.,Yamagata, Y.,Davis, S.J.,Ikemizu, S. Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans Nat.Immunol., 8:1001-1007, 2007 Cited by PubMed: 17643103DOI: 10.1038/ni1492 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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