2WJV

Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2

Summary for 2WJV

Entry DOI	10.2210/pdb2wjv/pdb
Related	1UW4 2IYK 2WJY
Descriptor	REGULATOR OF NONSENSE TRANSCRIPTS 1, REGULATOR OF NONSENSE TRANSCRIPTS 2, ZINC ION, ... (4 entities in total)
Functional Keywords	hydrolase, zinc-finger, atp-binding, rna-binding, nonsense-mediated mrna decay, nucleotide-binding, metal-binding
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm: Q92900 Cytoplasm, perinuclear region: Q9HAU5
Total number of polymer chains	4
Total formula weight	203850.90
Authors	Clerici, M.,Mourao, A.,Gutsche, I.,Gehring, N.H.,Hentze, M.W.,Kulozik, A.,Kadlec, J.,Sattler, M.,Cusack, S. (deposition date: 2009-06-01, release date: 2009-07-07, Last modification date: 2023-12-13)
Primary citation	Clerici, M.,Mourao, A.,Gutsche, I.,Gehring, N.H.,Hentze, M.W.,Kulozik, A.,Kadlec, J.,Sattler, M.,Cusack, S. Unusual Bipartite Mode of Interaction between the Nonsense-Mediated Decay Factors, Upf1 and Upf2. Embo J., 28:2293-, 2009 Cited by PubMed: 19556969 DOI: 10.1038/EMBOJ.2009.175 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation