Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003724 | molecular_function | RNA helicase activity |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016787 | molecular_function | hydrolase activity |
| D | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| E | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | CYS123 |
| A | CYS126 |
| A | CYS145 |
| A | HIS155 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 2 |
| Chain | Residue |
| A | CYS137 |
| A | SER140 |
| A | HIS159 |
| A | CYS165 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 3 |
| Chain | Residue |
| A | CYS186 |
| A | CYS209 |
| A | CYS213 |
| A | CYS183 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 987 |
| Chain | Residue |
| A | GLY497 |
| A | LYS498 |
| A | THR499 |
| A | VAL500 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 988 |
| Chain | Residue |
| A | GLY901 |
| A | PRO902 |
| A | ARG907 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 989 |
| Chain | Residue |
| A | MET357 |
| A | SER523 |
| A | ASN524 |
| A | ILE525 |
| A | ARG549 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 990 |
| Chain | Residue |
| A | PRO494 |
| A | GLN665 |
| A | ARG703 |
| A | GLY831 |
| A | ARG865 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 991 |
| Chain | Residue |
| A | TYR764 |
| A | ARG843 |
| A | HIS847 |
| A | GLN848 |
| A | GLY849 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 992 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 993 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 994 |
| Chain | Residue |
| A | ASN472 |
| A | HIS473 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 995 |
| Chain | Residue |
| A | ARG462 |
| A | PHE463 |
| A | THR464 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 996 |
| Chain | Residue |
| A | THR794 |
| A | PRO795 |
| A | SER825 |
| A | VAL826 |
| A | ASP827 |
| A | GLY851 |
| A | PHE852 |
| A | ARG858 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 997 |
| Chain | Residue |
| A | SER763 |
| A | PRO795 |
| A | TYR796 |
| A | GLU797 |
| A | ILE850 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 998 |
| Chain | Residue |
| A | THR418 |
| A | ARG422 |
| A | PRO623 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 999 |
| Chain | Residue |
| A | LEU544 |
| A | CYS545 |
| A | ALA546 |
| A | GLU550 |
| A | LEU561 |
| A | HIS562 |
| A | ARG624 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1 |
| Chain | Residue |
| B | CYS123 |
| B | CYS126 |
| B | CYS145 |
| B | HIS155 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 2 |
| Chain | Residue |
| B | CYS137 |
| B | SER140 |
| B | HIS159 |
| B | CYS165 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 3 |
| Chain | Residue |
| B | CYS183 |
| B | CYS186 |
| B | CYS209 |
| B | CYS213 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 989 |
| Chain | Residue |
| B | ASN472 |
| B | HIS473 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 990 |
| Chain | Residue |
| B | GLY497 |
| B | THR499 |
| B | VAL500 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 991 |
| Chain | Residue |
| B | TYR764 |
| B | ARG843 |
| B | HIS847 |
| B | GLN848 |
| B | GLY849 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B 992 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B 993 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 995 |
| Chain | Residue |
| B | ARG462 |
| B | PHE463 |
| B | THR464 |
| site_id | CC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 996 |
| Chain | Residue |
| B | THR794 |
| B | PRO795 |
| B | SER825 |
| B | VAL826 |
| B | ASP827 |
| B | GLY851 |
| B | PHE852 |
| B | ARG858 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 997 |
| Chain | Residue |
| B | SER763 |
| B | PRO795 |
| B | TYR796 |
| B | GLU797 |
| B | ILE850 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 998 |
| Chain | Residue |
| B | SER523 |
| B | ASN524 |
| B | ILE525 |
| B | ARG549 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 999 |
| Chain | Residue |
| B | PRO494 |
| B | GLN665 |
| B | ARG703 |
| B | GLY831 |
| B | ARG865 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 64 |
| Details | Region: {"description":"C3H","evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Region: {"description":"CC/SHH/C","evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Region: {"description":"C4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Region: {"description":"Interaction with UPF1"} |
