2WJV
Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | REGULATOR OF NONSENSE TRANSCRIPTS 1 | polymer | 800 | 89984.2 | 2 | UniProt (Q92900) Pfam (PF09416) Pfam (PF18141) Pfam (PF13086) Pfam (PF13087) | HOMO SAPIENS (HUMAN) | UPF1, ATP-DEPENDENT HELICASE RENT1, NONSENSE MRNA REDUCING FACTOR 1, UP-FRAMESHIFT SUPPRESSOR 1 HOMOLOG, NORF1, HUPF1 |
| 2 | C, D (D, E) | REGULATOR OF NONSENSE TRANSCRIPTS 2 | polymer | 97 | 10640.3 | 2 | UniProt (Q9HAU5) Pfam (PF04050) | HOMO SAPIENS (HUMAN) | UPF2, NONSENSE MRNA REDUCING FACTOR 2, UP-FRAMESHIFT SUPPRESSOR 2 HOMOLOG, HUPF2 |
| 3 | E, F, G, U, V... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | AA, BA, CA, DA, EA... (B, A) | SULFATE ION | non-polymer | 96.1 | 23 | Chemie (SO4) |
Sequence modifications
D, E: 1105 - 1198 (UniProt: Q9HAU5)
| PDB | External Database | Details |
|---|---|---|
| Ala 1102 | - | expression tag |
| Met 1103 | - | expression tag |
| Gly 1104 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 201249.0 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 2601.9 | |
| All* | Total formula weight | 203850.9 |
