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2W9E

Structure of ICSM 18 (anti-Prp therapeutic antibody) Fab fragment complexed with human Prp fragment 119-231

Summary for 2W9E
Entry DOI10.2210/pdb2w9e/pdb
Related1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3
DescriptorMAJOR PRION PROTEIN, ICSM 18-ANTI-PRP THERAPEUTIC FAB HEAVY CHAIN, ICSM 18-ANTI-PRP THERAPEUTIC FAB LIGHT CHAIN, ... (5 entities in total)
Functional Keywordsfab, prp, prion, membrane, gpi-anchor, lipoprotein, golgi apparatus, disease mutation, immune system, glycoprotein, cell membrane
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationCell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Cytoplasm: P04156
Total number of polymer chains3
Total formula weight59657.04
Authors
Primary citationAntonyuk, S.V.,Trevitt, C.R.,Strange, R.W.,Jackson, G.S.,Sangar, D.,Batchelor, M.,Cooper, S.,Fraser, C.,Jones, S.,Georgiou, T.,Khalili-Shirazi, A.,Clarke, A.R.,Hasnain, S.S.,Collinge, J.
Crystal Structure of Human Prion Protein Bound to a Therapeutic Antibody.
Proc.Natl.Acad.Sci.USA, 106:2554-, 2009
Cited by
PubMed: 19204296
DOI: 10.1073/PNAS.0809170106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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