2VAG
Crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor
Summary for 2VAG
Entry DOI | 10.2210/pdb2vag/pdb |
Related | 1Z57 |
Descriptor | DUAL SPECIFICITY PROTEIN KINASE CLK1, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, tyrosine-protein kinase, nucleus, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: P49759 |
Total number of polymer chains | 1 |
Total formula weight | 40079.66 |
Authors | Pike, A.C.W.,Bullock, A.N.,Fedorov, O.,Pilka, E.S.,Ugochukwu, E.,von Delft, F.,Edwards, A.,Arrowsmith, C.H.,Weigelt, J.,Sundstrom, M.,Huber, K.,Bracher, F.,Knapp, S. (deposition date: 2007-08-31, release date: 2007-10-09, Last modification date: 2023-12-13) |
Primary citation | Fedorov, O.,Huber, K.,Eisenreich, A.,Filippakopoulos, P.,King, O.,Bullock, A.N.,Szklarczyk, D.,Jensen, L.J.,Fabbro, D.,Trappe, J.,Rauch, U.,Bracher, F.,Knapp, S. Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing. Chem.Biol, 18:67-, 2011 Cited by PubMed: 21276940DOI: 10.1016/J.CHEMBIOL.2010.11.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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