2VA2

Complex structure of Sulfolobus solfataricus DPO4 and DNA duplex containing a hydrophobic thymine isostere 2,4-difluorotoluene nucleotide in the template strand

Summary for 2VA2

• Entry DOI: 10.2210/pdb2va2/pdb
• Related: 2V9W 2VA3
• Descriptor: DNA POLYMERASE IV, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *CP*TP*A)-3', 5'-D(*TP*TP*CP*AP*GP*DFTP*AP*GP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... (6 entities in total)
• Functional Keywords: transferase-dna complex, dna-directed dna polymerase, p2 dna polymerase iv, transferase, nucleotidyltransferase, mutator protein, dna replication, dna repair, dna-binding, metal-binding, translesion dna polymerase, 2, ddctp, magnesium, dna damage, transferase/dna
• Biological source: SULFOLOBUS SOLFATARICUS
• Cellular location: Cytoplasm (Probable): Q97W02
• Total number of polymer chains: 6
• Total formula weight: 102288.63

Authors

Irimia, A.,Pallan, P.S.,Egli, M. (deposition date: 2007-08-28, release date: 2007-10-30, Last modification date: 2023-12-13)

• Primary citation: Irimia, A.,Eoff, R.L.,Pallan, P.S.,Guengerich, F.P.,Egli, M.; Structure and Activity of Y-Class DNA Polymerase Dpo4 from Sulfolobus Solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4- Difluorotoluene.; J.Biol.Chem., 282:36421-, 2007; PubMed: 17951245; DOI: 10.1074/JBC.M707267200

Experimental method

X-RAY DIFFRACTION (2.8 Å)