2V9W

Complex structure of Sulfolobus solfataricus DPO4 and DNA duplex containing a hydrophobic thymine isostere 2,4-difluorotoluene nucleotide in the template strand

Summary for 2V9W

• Entry DOI: 10.2210/pdb2v9w/pdb
• Related: 1JX4 1JXL 1N48 1N56 1RYR 1RYS 1S0M 1S0N 1S0O 1S10 1S97 1S9F 2AGO 2AGP 2AGQ 2ASD 2ASJ 2ASL 2ATL 2AU0 2BQ3 2BQR 2BQU 2BR0 2C22 2C28 2C2D 2C2E 2C2R 2J6S 2J6T 2J6U 2JEF 2JEG 2JEI 2JEJ 2UVR 2UVU 2UVV 2UVW 2VA2 2VA3
• Descriptor: DNA POLYMERASE IV, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *CP*TP*G)-3', 5'-D(*TP*TP*CP*AP*GP*DFTP*AP*GP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... (6 entities in total)
• Functional Keywords: dna-directed dna polymerase, p2 dna polymerase iv, nucleotidyltransferase, mutator protein, dna replication, 4-difluorotoluene, dna repair, dna-binding, transferase, metal-binding, translesion dna polymerase, ddctp, cytoplasm, magnesium, dna damage
• Biological source: SULFOLOBUS SOLFATARICUS
• Cellular location: Cytoplasm (Probable): Q97W02
• Total number of polymer chains: 6
• Total formula weight: 102240.47

Authors

Irimia, A.,Pallan, P.S.,Egli, M. (deposition date: 2007-08-27, release date: 2007-10-30, Last modification date: 2023-12-13)

• Primary citation: Irimia, A.,Eoff, R.L.,Pallan, P.S.,Guengerich, F.P.,Egli, M.; Structure and Activity of Y-Class DNA Polymerase Dpo4 from Sulfolobus Solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4-Difluorotoluene.; J.Biol.Chem., 282:36421-, 2007; PubMed: 17951245; DOI: 10.1074/JBC.M707267200

Experimental method

X-RAY DIFFRACTION (3 Å)