2W8L

Y-family DNA polymerase Dpo4 bypassing N2-naphthyl-guanine adduct in anti orientation

Replaces:  2V4T

Summary for 2W8L

• Entry DOI: 10.2210/pdb2w8l/pdb
• Related: 1JX4 1JXL 1N48 1N56 1RYR 1RYS 1S0M 1S0N 1S0O 1S10 1S97 1S9F 2AGO 2AGP 2AGQ 2ASD 2ASJ 2ASL 2ATL 2AU0 2BQ3 2BQR 2BQU 2BR0 2C22 2C28 2C2D 2C2E 2C2R 2J6S 2J6T 2J6U 2JEF 2JEG 2JEI 2JEJ 2UVR 2UVU 2UVV 2UVW 2V4Q 2V4R 2V9W 2VA2 2VA3 2W8K
• Descriptor: DNA POLYMERASE IV, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*DOC)-3', 5'-D(*TP*CP*AP*CP*N2GP*GP*AP*AP*TP*CP *CP*TP*TP*CP*CP*CP*CP*C)-3', ... (6 entities in total)
• Functional Keywords: dna-directed dna polymerase, dna, dpo4, adduct, n2-alkyl, cytoplasm, magnesium, transferase, metal-binding, mutator protein, dna replication, nucleotidyltransferase, complex, polymerase, dna damage, dna repair, dna-binding, transferase/dna, transferase-dna complex
• Biological source: SULFOLOBUS SOLFATARICUS
• Cellular location: Cytoplasm (Probable): Q97W02
• Total number of polymer chains: 3
• Total formula weight: 51549.37

Authors

Eoff, R.L.,Zhang, H.,Egli, M.,Guengerich, F.P. (deposition date: 2009-01-16, release date: 2009-01-27, Last modification date: 2023-12-13)

• Primary citation: Zhang, H.,Eoff, R.L.,Kozekov, I.D.,Rizzo, C.J.,Egli, M.,Guengerich, F.P.; Versatility of Y-Family Sulfolobus Solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine Adducts.; J.Biol.Chem., 284:3563-, 2009; PubMed: 19059910; DOI: 10.1074/JBC.M807778200

Experimental method

X-RAY DIFFRACTION (3 Å)