2QUZ
Crystal Structure of the activating H-RasK117R mutant in Costello Syndrome, bound to Mg-GDP
Summary for 2QUZ
Entry DOI | 10.2210/pdb2quz/pdb |
Descriptor | GTPase HRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | hydrolase, gtpase protein, costello syndrome, ras protein, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side: P01112 |
Total number of polymer chains | 1 |
Total formula weight | 19370.71 |
Authors | Parret, A.,Scheffzek, K. (deposition date: 2007-08-07, release date: 2007-12-11, Last modification date: 2023-08-30) |
Primary citation | Denayer, E.,Parret, A.,Chmara, M.,Schubbert, S.,Vogels, A.,Devriendt, K.,Frijns, J.P.,Rybin, V.,de Ravel, T.J.,Shannon, K.,Cools, J.,Scheffzek, K.,Legius, E. Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation. Hum.Mutat., 29:232-239, 2008 Cited by PubMed: 17979197DOI: 10.1002/humu.20616 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
Download full validation report