2PGQ
Human thrombin mutant C191A-C220A in complex with the inhibitor PPACK
Summary for 2PGQ
Entry DOI | 10.2210/pdb2pgq/pdb |
Related | 1SHH 2PGB |
Related PRD ID | PRD_000020 |
Descriptor | Thrombin light chain, Thrombin heavy chain, ZINC ION, ... (6 entities in total) |
Functional Keywords | serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 35868.32 |
Authors | Bush-Pelc, L.A.,Marino, F.,Chen, Z.,Pineda, A.O.,Mathews, F.S.,Di Cera, E. (deposition date: 2007-04-10, release date: 2007-07-17, Last modification date: 2024-03-13) |
Primary citation | Bush-Pelc, L.A.,Marino, F.,Chen, Z.,Pineda, A.O.,Mathews, F.S.,Di Cera, E. Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery J.Biol.Chem., 282:27165-27170, 2007 Cited by PubMed: 17636263DOI: 10.1074/jbc.M703202200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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