2PGQ
Human thrombin mutant C191A-C220A in complex with the inhibitor PPACK
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thrombin light chain | polymer | 45 | 5280.8 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (B) | Thrombin heavy chain | polymer | 259 | 29716.1 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | C, D, G (A, B) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | E (B) | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 1 | BIRD (PRD_000020) Chemie (0G6) | |||
| 5 | F (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 304 | Chemie (HOH) |
Sequence modifications
B: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 191 | Cys 564 | engineered mutation |
| Ala 220 | Cys 594 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34996.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 871.4 | |
| All* | Total formula weight | 35868.3 |
