2NSX
Structure of acid-beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease
Summary for 2NSX
Entry DOI | 10.2210/pdb2nsx/pdb |
Descriptor | Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (6 entities in total) |
Functional Keywords | tim-barrel glycosidase cerezyme hydrolysis, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 225874.38 |
Authors | Lieberman, R.L.,Petsko, G.A.,Ringe, D. (deposition date: 2006-11-06, release date: 2006-12-26, Last modification date: 2023-08-30) |
Primary citation | Lieberman, R.L.,Wustman, B.A.,Huertas, P.,Powe, A.C.,Pine, C.W.,Khanna, R.,Schlossmacher, M.G.,Ringe, D.,Petsko, G.A. Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. Nat.Chem.Biol., 3:101-107, 2007 Cited by PubMed: 17187079DOI: 10.1038/nchembio850 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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