2MKC

Cooperative Structure of the Heterotrimeric pre-mRNA Retention and Splicing Complex

Summary for 2MKC

Entry DOI	10.2210/pdb2mkc/pdb
NMR Information	BMRB: 19766
Descriptor	U2 snRNP component IST3, Pre-mRNA leakage protein 1, Pre-mRNA-splicing factor CWC26 (3 entities in total)
Functional Keywords	spliceosome, snu17p, bud13p, pml1p, heterotrimer, cooperativity, res, splicing, rrm, protein binding, ist3p
Biological source	Saccharomyces cerevisiae (Baker's yeast) More
Cellular location	Cytoplasm: P40565 Q07930 P46947
Total number of polymer chains	3
Total formula weight	19838.95
Authors	Wysoczanski, P.,Schneider, C.,Xiang, S.,Munari, F.,Trowitzsch, S.,Wahl, M.C.,Luhrmann, R.,Becker, S.,Zweckstetter, M. (deposition date: 2014-02-04, release date: 2014-09-03, Last modification date: 2023-06-14)
Primary citation	Wysoczanski, P.,Schneider, C.,Xiang, S.,Munari, F.,Trowitzsch, S.,Wahl, M.C.,Luhrmann, R.,Becker, S.,Zweckstetter, M. Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nat.Struct.Mol.Biol., 21:911-918, 2014 Cited by PubMed: 25218446 DOI: 10.1038/nsmb.2889 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation