2LMS

A single GalNAc residue on Threonine-106 modifies the dynamics and the structure of Interferon alpha-2a around the glycosylation site

Summary for 2LMS

Entry DOI	10.2210/pdb2lms/pdb
NMR Information	BMRB: 18135
Descriptor	Interferon alpha-2, 2-acetamido-2-deoxy-alpha-D-galactopyranose (2 entities in total)
Functional Keywords	cytokine, glycoprotein, o-glycosylation, signaling protein, type i interferons, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	19616.50
Authors	Ghasriani, H.,Belcourt, P.J.F.,Sauve, S.,Hodgson, D.J.,Gingras, G.,Brochu, D.,Gilbert, M.,Aubin, Y. (deposition date: 2011-12-12, release date: 2012-12-05, Last modification date: 2023-06-14)
Primary citation	Ghasriani, H.,Belcourt, P.J.,Sauve, S.,Hodgson, D.J.,Brochu, D.,Gilbert, M.,Aubin, Y. A single N-acetylgalactosamine residue at threonine 106 modifies the dynamics and structure of interferon alpha2a around the glycosylation site. J.Biol.Chem., 288:247-254, 2013 Cited by PubMed: 23184955 DOI: 10.1074/jbc.M112.413252 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation