2LMS

A single GalNAc residue on Threonine-106 modifies the dynamics and the structure of Interferon alpha-2a around the glycosylation site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002286	biological_process	T cell activation involved in immune response
A	0002323	biological_process	natural killer cell activation involved in immune response
A	0005125	molecular_function	cytokine activity
A	0005126	molecular_function	cytokine receptor binding
A	0005132	molecular_function	type I interferon receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006915	biological_process	apoptotic process
A	0006952	biological_process	defense response
A	0006954	biological_process	inflammatory response
A	0006959	biological_process	humoral immune response
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007267	biological_process	cell-cell signaling
A	0010629	biological_process	negative regulation of gene expression
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0030183	biological_process	B cell differentiation
A	0032696	biological_process	negative regulation of interleukin-13 production
A	0032714	biological_process	negative regulation of interleukin-5 production
A	0042100	biological_process	B cell proliferation
A	0043330	biological_process	response to exogenous dsRNA
A	0045581	biological_process	negative regulation of T cell differentiation
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046597	biological_process	negative regulation of viral entry into host cell
A	0051607	biological_process	defense response to virus
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0097696	biological_process	cell surface receptor signaling pathway via STAT
A	0098586	biological_process	cellular response to virus
A	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production

Functional Information from PROSITE/UniProt

site_id	PS00252
Number of Residues	19
Details	INTERFERON_A_B_D Interferon alpha, beta and delta family signature. YFqRItlYLkekkyspCAW

Chain	Residue	Details
A	TYR122-TRP140

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2049076

Chain	Residue	Details
A	THR106

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