2L28

Solution structure of lactobacillus casei dihydrofolate reductase apo-form, 25 conformers

Summary for 2L28

Entry DOI	10.2210/pdb2l28/pdb
Related	1LUD 1YHO 2HM9 2HQP
NMR Information	BMRB: 17125
Descriptor	Dihydrofolate reductase (1 entity in total)
Functional Keywords	oxidoreductase, dhfr, antifolates, co-operative binding
Biological source	Lactobacillus casei
Total number of polymer chains	1
Total formula weight	18331.59
Authors	Polshakov, V.I.,Birdsall, B.,Feeney, J. (deposition date: 2010-08-13, release date: 2011-04-06, Last modification date: 2011-07-13)
Primary citation	Feeney, J.,Birdsall, B.,Kovalevskaya, N.V.,Smurnyy, Y.D.,Navarro Peran, E.M.,Polshakov, V.I. NMR Structures of Apo L. casei Dihydrofolate Reductase and Its Complexes with Trimethoprim and NADPH: Contributions to Positive Cooperative Binding from Ligand-Induced Refolding, Conformational Changes, and Interligand Hydrophobic Interactions. Biochemistry, 50:3609-3620, 2011 Cited by PubMed: 21410224 DOI: 10.1021/bi200067t PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation