2HM9
Solution structure of dihydrofolate reductase complexed with trimethoprim, 33 structures
Summary for 2HM9
Entry DOI | 10.2210/pdb2hm9/pdb |
Related | 1AO8 1BZF 1LUD 1YHO 2L28 3DFR 3HQP |
Descriptor | Dihydrofolate reductase, 2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM (2 entities in total) |
Functional Keywords | oxidoreductase, dhfr, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Lactobacillus casei |
Total number of polymer chains | 1 |
Total formula weight | 18622.92 |
Authors | Polshakov, V.I.,Birdsall, B. (deposition date: 2006-07-11, release date: 2007-06-05, Last modification date: 2011-07-13) |
Primary citation | Feeney, J.,Birdsall, B.,Kovalevskaya, N.V.,Smurnyy, Y.D.,Navarro-Peran, E.M.,Polshakov, V.I. NMR structures of apo L.casei dihydrofolate reductase and its complexes with trimethoprim and NADPH. Contributions to positive cooperative binding from ligand-induced refolding, conformational changes and interligand hydrophobic interactions Biochemistry, 2011 Cited by PubMed: 21410224DOI: 10.1021/bi200067t PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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