2KQP

NMR Structure of Proinsulin

Summary for 2KQP
NMR InformationBMRB: 16608
DescriptorInsulin (1 entity in total)
Functional Keywordsproinsulin, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, disulfide bond, glucose metabolism, hormone, pharmaceutical, secreted
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P01308
Total number of polymer chains1
Total formula weight9379.58
Authors
Yang, Y.,Hua, Q.X.,Mackin, R.B.,Weiss, M.A. (deposition date: 2009-11-12, release date: 2010-01-26, Last modification date: 2011-07-13)
Primary citationChoquette, M.H.,Hua, Q.X.,Liu, J.,Mackin, R.B.,Shimizu, E.H.,Weiss, M.A.,Yang, Y.
Solution structure of proinsulin: connecting domain flexibility and prohormone processing.
J.Biol.Chem., 285:7847-7851, 2010
PubMed: 20106974
DOI: 110.1074/jbc.C109.084921
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation
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PDB entries from 2021-06-23