2KJU

NMR structure of human insulin mutant glu-b21-d-glu, his-b10 asp pro-b28-lys, lys-b29-pro, 20 structures

Summary for 2KJU
Related2KJJ
DescriptorInsulin (2 entities in total)
Functional Keywordshormone, human insulin, mutant, fibrillation, stability, carbohydrate metabolism, cleavage on pair of basic residues, disulfide bond, glucose metabolism, secreted, diabetes mellitus, disease mutation, pharmaceutical, immune system
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5794.59
Authors
Hua, Q.X.,Huang, K.,Hu, S.Q.,Katsoyanni, P.,Weiss, M.A. (deposition date: 2009-06-10, release date: 2010-06-16, Last modification date: 2011-07-13)
Primary citationHu, S.Q.,Hua, Q.X.,Huang, K.,Katsoyanni, P.,Weiss, M.A.
Acceleration of Protein Fibrillation by Chiral Destabilization of Beta-Turn
To be Published,
Experimental method
SOLUTION NMR
Structure validation
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PDB entries from 2021-06-16