2K9E
NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide
Summary for 2K9E
Entry DOI | 10.2210/pdb2k9e/pdb |
NMR Information | BMRB: 15983 |
Descriptor | Kappa-stichotoxin-She3a (1 entity in total) |
Functional Keywords | protein, ionic channel inhibitor, nematocyst, neurotoxin, potassium channel inhibitor, secreted, toxin |
Biological source | Stichodactyla helianthus |
Total number of polymer chains | 1 |
Total formula weight | 4422.17 |
Authors | Galea, C.A. (deposition date: 2008-10-09, release date: 2009-01-20, Last modification date: 2023-11-15) |
Primary citation | Pennington, M.W.,Beeton, C.,Galea, C.A.,Smith, B.J.,Chi, V.,Monaghan, K.P.,Garcia, A.,Rangaraju, S.,Giuffrida, A.,Plank, D.,Crossley, G.,Nugent, D.,Khaytin, I.,Lefievre, Y.,Peshenko, I.,Dixon, C.,Chauhan, S.,Orzel, A.,Inoue, T.,Hu, X.,Moore, R.V.,Norton, R.S.,Chandy, K.G. Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes Mol.Pharmacol., 75:762-773, 2009 Cited by PubMed: 19122005DOI: 10.1124/mol.108.052704 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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