2HU6

Crystal structure of human MMP-12 in complex with acetohydroxamic acid and a bicyclic inhibitor

Summary for 2HU6

Entry DOI	10.2210/pdb2hu6/pdb
Related	1RMZ 1Y93
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (6 entities in total)
Functional Keywords	mmp-12, matrix metalloproteinase, macrophage metalloelastase, inhibitor, hydroxamic acid, drug design, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains	1
Total formula weight	18325.19
Authors	Mannino, C.,Nievo, M.,Machetti, F.,Papakyriakou, A.,Calderone, V.,Fragai, M.,Guarna, A. (deposition date: 2006-07-26, release date: 2006-12-19, Last modification date: 2023-08-30)
Primary citation	Mannino, C.,Nievo, M.,Machetti, F.,Papakyriakou, A.,Calderone, V.,Fragai, M.,Guarna, A. Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors. Bioorg.Med.Chem., 14:7392-7403, 2006 Cited by PubMed: 16899369 DOI: 10.1016/j.bmc.2006.07.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.32 Å)

Structure validation