2H55

Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-DZ8

Summary for 2H55

Entry DOI	10.2210/pdb2h55/pdb
Related	1UY6 1ZW9 2FWY 2FWZ
Descriptor	Heat shock protein HSP 90-alpha 4, 2-FLUORO-8-[(6-IODO-1,3-BENZODIOXOL-5-YL)METHYL]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE (3 entities in total)
Functional Keywords	hsp90, grp94, chaperone, purine, pu3, h64, h71, dz8
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	29285.47
Authors	Immormino, R.M.,Gewirth, D.T. (deposition date: 2006-05-25, release date: 2006-10-03, Last modification date: 2023-08-30)
Primary citation	Immormino, R.M.,Kang, Y.,Chiosis, G.,Gewirth, D.T. Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors. J.Med.Chem., 49:4953-4960, 2006 Cited by PubMed: 16884307 DOI: 10.1021/jm060297x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation