2H55
Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-DZ8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heat shock protein HSP 90-alpha 4 | polymer | 256 | 28773.1 | 1 | UniProt (Q5CAQ6) Pfam (PF13589) UniProt (by SIFTS) (P07900) | Homo sapiens (human) | HSP90 PROTEIN |
| 2 | B (A) | 2-FLUORO-8-[(6-IODO-1,3-BENZODIOXOL-5-YL)METHYL]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE | non-polymer | 512.3 | 1 | Chemie (DZ8) | |||
| 3 | C (A) | water | water | 18.0 | 315 | Chemie (HOH) |
Sequence modifications
A: 1 - 236 (UniProt: Q5CAQ6)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | cloning artifact |
| Gly -18 | - | cloning artifact |
| Ser -17 | - | cloning artifact |
| Ser -16 | - | cloning artifact |
| His -15 | - | cloning artifact |
| His -14 | - | cloning artifact |
| His -13 | - | cloning artifact |
| His -12 | - | cloning artifact |
| His -11 | - | cloning artifact |
| His -10 | - | cloning artifact |
| Ser -9 | - | cloning artifact |
| Ser -8 | - | cloning artifact |
| Gly -7 | - | cloning artifact |
| Leu -6 | - | cloning artifact |
| Val -5 | - | cloning artifact |
| Pro -4 | - | cloning artifact |
| Arg -3 | - | cloning artifact |
| Gly -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28773.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 512.3 | |
| All* | Total formula weight | 29285.5 |
