2FKY
crystal structure of KSP in complex with inhibitor 13
Summary for 2FKY
Entry DOI | 10.2210/pdb2fky/pdb |
Related | 2FL2 2FL6 |
Descriptor | Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | ksp, ksp-inhibitor complex, cell cycle |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P52732 |
Total number of polymer chains | 2 |
Total formula weight | 83546.71 |
Authors | |
Primary citation | Fraley, M.E.,Garbaccio, R.M.,Arrington, K.L.,Hoffman, W.F.,Tasber, E.S.,Coleman, P.J.,Buser, C.A.,Walsh, E.S.,Hamilton, K.,Fernandes, C.,Schaber, M.D.,Lobell, R.B.,Tao, W.,South, V.J.,Yan, Y.,Kuo, L.C.,Prueksaritanont, T.,Shu, C.,Torrent, M.,Heimbrook, D.C.,Kohl, N.E.,Huber, H.E.,Hartman, G.D. Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. Bioorg.Med.Chem.Lett., 16:1775-1779, 2006 Cited by PubMed: 16439123DOI: 10.1016/j.bmcl.2006.01.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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