2F16

Crystal structure of the yeast 20S proteasome in complex with bortezomib

Summary for 2F16

• Entry DOI: 10.2210/pdb2f16/pdb
• Related: 1PMA 1RYP
• Descriptor: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
• Functional Keywords: beta-sandwich flanked by helices, complex structure covalently bound to the synthetic inihibtor bortezomib, hydrolase
• Biological source: Saccharomyces cerevisiae (baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 706511.66

Authors

Groll, M. (deposition date: 2005-11-14, release date: 2006-03-21, Last modification date: 2023-08-23)

• Primary citation: Groll, M.,Berkers, C.R.,Ploegh, H.L.,Ovaa, H.; Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome.; Structure, 14:451-456, 2006; PubMed: 16531229; DOI: 10.1016/j.str.2005.11.019

Experimental method

X-RAY DIFFRACTION (2.8 Å)