2EWY
Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor
Summary for 2EWY
Entry DOI | 10.2210/pdb2ewy/pdb |
Descriptor | Beta-secretase 2, N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHYLBENZYL)AMINO]PROPYL}DIBENZO[B,F]OXEPINE-10-CARBOXAMIDE (3 entities in total) |
Functional Keywords | bace2, aspartic protease, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: Q9Y5Z0 |
Total number of polymer chains | 4 |
Total formula weight | 169110.63 |
Authors | Ostermann, N. (deposition date: 2005-11-07, release date: 2006-11-07, Last modification date: 2023-08-23) |
Primary citation | Ostermann, N.,Eder, J.,Eidhoff, U.,Zink, F.,Hassiepen, U.,Worpenberg, S.,Maibaum, J.,Simic, O.,Hommel, U.,Gerhartz, B. Crystal structure of human BACE2 in complex with a hydroxyethylamine transition state inhibitor J.Mol.Biol., 355:249-261, 2006 Cited by PubMed: 16305800DOI: 10.1016/j.jmb.2005.10.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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