2AOU
Histamine Methyltransferase Complexed with the Antimalarial Drug Amodiaquine
Summary for 2AOU
Entry DOI | 10.2210/pdb2aou/pdb |
Related | 1JQD 1JQE 2AOT 2AOV 2AOW 2AOX |
Descriptor | Histamine N-methyltransferase, 4-[(7-CHLOROQUINOLIN-4-YL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL, ... (4 entities in total) |
Functional Keywords | classic methyltransferase fold, protein-drug complex, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P50135 P50135 |
Total number of polymer chains | 2 |
Total formula weight | 68121.48 |
Authors | Horton, J.R.,Sawada, K.,Nishibori, M.,Cheng, X. (deposition date: 2005-08-14, release date: 2005-09-13, Last modification date: 2023-11-15) |
Primary citation | Horton, J.R.,Sawada, K.,Nishibori, M.,Cheng, X. Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353:334-344, 2005 Cited by PubMed: 16168438DOI: 10.1016/j.jmb.2005.08.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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